Sono nucleation
The application of power ultrasound to crystallization processes has been shown to offer considerable potential for controlling the physical characteristics of
crystalline products.
Crystallization is very commonly used for the isolation of drug actives from the final stage of a synthesis route. It potentially combines product purification and consolidation as a convenient solid form, and a well-designed process operating efficiently will consistently yield a product in a specified crystal morphology, size distribution and habit (shape).
Although ultrasonic technology has been available for many years in research
and diagnostics, its application to chemical processes has developed rapidly
in recent years. The new covaris focused acoustic sonic's technology allows the application of controllable high intensities on
potentially industrially scales.
Sono-crystallisation is possible by reducing the metastable zone width. When this is reduced, the quality of the crystals is dramatically improved. Furthermore, the induction time for supersaturation is reduced. Covaris AFA sonication also creates secondary nuclei by breaking up aggregates and returning them to solution as potential nuclei.
Covaris ultrasound operates between 300khz and 1MHz, is PC configurable and allows non contact & relatively isothermal intense energy delivery in batch or cont flow mode.
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 video sono nucleation & crystallisation |
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